We agree with Carruthers that evidence for metacognition in species lacking mindreading provides dramatic evidence in favor of the metacognition-is-prior account and against the mindreading-is-prior account. We discuss this existing evidence and explain why an evolutionary perspective favors the former account and poses serious problems for the latter account.

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

Michael A. PetersBeijing Normal UniversityMy deepest condolences to Pepe, Dom and Marcus and to Jim’s grandchildren. Tina and I spent a lot of time at the Marshall family home, often attending dinn...

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

We applaud Aggleton & Brown's affirmation of limbic diencephalic-hippocampal interaction as a key memory substrate. However, we do not agree with a thesis of diencephalic-hippocampal strict dedication to episodic memory. Instead, this circuitry supports the production of context-specific patterns of activation that subserve retrieval for a broad class of memory phenomena, including goal-directed instrumental behavior of animals and episodic memory of humans.

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

Widely regarded as one of the most important and influential sports books of all time, C. L. R. James's _Beyond a Boundary_ is—among other things—a pioneering study of popular culture, an analysis of resistance to empire and racism, and a personal reflection on the history of colonialism and its effects in the Caribbean. More than fifty years after the publication of James's classic text, the contributors to _Marxism, Colonialism, and Cricket_ investigate _Beyond a Boundary_'s production and reception and its implication (...) for debates about sports, gender, aesthetics, race, popular culture, politics, imperialism, and English and Caribbean identity. Including a previously unseen first draft of _Beyond a Boundary_'s conclusion alongside contributions from James's key collaborator Selma James and from Michael Brearley, former captain of the English Test cricket team, _Marxism, Colonialism, and Cricket_ provides a thorough and nuanced examination of James's groundbreaking work and its lasting impact. Contributors. Anima Adjepong, David Austin, Hilary McD. Beckles, Michael Brearley, Selwyn R. Cudjoe, David Featherstone, Christopher Gair, Paget Henry, Christian Høgsbjerg, C. L. R. James, Selma James, Roy McCree, Minkah Makalani, Clem Seecharan, Andrew Smith, Neil Washbourne, Claire Westall. (shrink)

According to the standard story of action, a story that can be traced back at least to David Hume , actions are those bodily movements that are caused and rationalized by a pair of mental states: a desire for some end, where ends can be thought of as ways the world could be, and a belief that something the agent can just do, namely, move her body in the way to be explained, has some suitable chance of making the (...) world the relevant way. Bodily movements that occur otherwise aren't actions, they are mere happenings. (shrink)

What determines whether an action is right or wrong? Morality, Rules, and Consequences: A Critical Reader explores for students and researchers the relationship between consequentialist theory and moral rules. Most of the chapters focus on rule consequentialism or on the distinction between act and rule versions of consequentialism. Contributors, among them the leading philosophers in the discipline, suggest ways of assessing whether rule consequentialism could be a satisfactory moral theory. These essays, all of which are previously unpublished, provide students in (...) moral philosophy with essential material and ask key questions on just what the criteria for an adequate moral theory might be. (shrink)

We would like to thank the commentators for their generous comments, valuable insights and helpful suggestions. We begin this response by discussing the selfishness axiom and the importance of the preferences, beliefs, and constraints framework as a way of modeling some of the proximate influences on human behavior. Next, we broaden the discussion to ultimate-level (that is evolutionary) explanations, where we review and clarify gene-culture coevolutionary theory, and then tackle the possibility that evolutionary approaches that exclude culture might be sufficient (...) to explain the data. Finally, we consider various methodological and epistemological concerns expressed by our commentators. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

This chapter contains sections titled: References Further reading.

This book celebrates the work of Patricia Werhane, an iconic figure in business ethics. This festschrift is a collection of articles that build on Werhane’s contributions to business ethics in such areas as Employee Rights, the Legacy of Adam Smith, Moral Imagination, Women in Business, the development of the field of business ethics, and her contributions to such fields as Health Care, Education, Teaching, and Philosophy. All papers are new contributions to the management literature written by well-known business ethicists, (...) such as Norman Bowie, Richard De George, Ronald Duska, Edwin Hartman, Michael Hoffman, Mollie Painter-Morland, Mark Schwartz, Andrew Wicks, and others. The volume is comprised of articles that reflect on Werhane’s work as well as build on it as a way to advance further research. At the end of the festschrift, Pat Werhane provides responses to each chapter. The first chapter of the book also includes the overview of Patricia Werhane’s work and her academic career. The book is written to appeal to management scholars and graduate students interested in the areas of Business Ethics, Modern Capitalism, and Human Rights. Patricia Werhane is one of the most distinguished figures in the field of business ethics. She was a founder of the field, she is one of its leading scholars, and she has had a profound impact on the world of business practice. Among her many accomplishments, Pat is known for her original work on moral imagination, she is an acclaimed authority on employee rights in the workplace, and she is one of the leading scholars on Adam Smith. Having been active in Academia for over 50 years, Werhane is a prolific author of over a hundred articles and book chapters, and the author or editor of twenty-seven books, including Adam Smith and his Legacy for Modern Capitalism, Moral Imagination and Management Decision-Making, and co-authored books Organization Ethics in Health Care, Alleviating Poverty Through Profitable Partnerships, Obstacles to Ethical Decision-Making, Corporate Responsibility: The American Experience, and Research Approaches to Business Ethics and Corporate Responsibility. (shrink)

In this book philosophers, scholars of religion, and activists address the theme of responsibility. Barbara Darling-Smith brings together an enlightening collection of essays that analyze the ethics of responsibility, its relational nature, and its global struggle.

Michael Slote’s Moral Sentimentalism is a wonderful model of a particular, under-appreciated philosophical method. It demonstrates that exciting, original work can be created by putting old ideas to new uses, proving once again that the classics of moral and political philosophy offer too rich an array of intellectual resources to leave to historians alone. Whenever one is reclaiming old ideas, however, the most important decision is which ideas to reclaim, and which to leave in the dustbin of history. Slote (...) makes use of many ideas drawn from history’s greatest moral sentimentalist, David Hume, but he rejects many others. The work of Hume’s closest friend and greatest sentimentalist ally, Adam Smith, is rejected without adequate explanation. Smith is mentioned, but quickly dismissed. Yet even though Smith makes little contribution to Slote’s own version of sentimentalism, I think he deserved greater discussion in this book. Smith and Slote address many of the same subjects, using the same basic sentimentalist approach, but they come to very different conclusions. It is thus possible to construct a fruitful debate between them—a debate in which, since he can no longer speak on his own behalf, I will be taking Smith’s side. (shrink)

What role do general principles play in our moral judgment? This question has been much contested among moral theorists of the last fifteen years. When we turn to the British moralists of the eighteenth century, we find that the same question was equally pressing. In this paper, I show that while many of the British moralists thought that general principles could conclusively determine our moral duties, David Hume and Adam Smith were ambivalent about the role of moral principles, (...) not only giving expression to the common view of principles’ power but also exploring the possibility that principles could not fill the justificatory space typically allotted them. Hume and Smith, I show, constitute fascinating transitional figures in our thinking about the role of general moral principles. (shrink)

In this expansive and provocative new work, Michael Dango theorizes how aesthetic style manages crisis--and why taking crisis seriously means taking aesthetics seriously. Detoxing, filtering, binging, and ghosting: these are four actions that have come to define how people deal with the stress of living in a world that seems in permanent crisis. As Dango argues, they can also be used to describe contemporary art and literature. Employing what he calls "promiscuous archives," Dango traverses media and re-shuffles literary and (...) art historical genealogies to make his case. The book discusses social media filters alongside the minimalism of Donald Judd and La Monte Young and the television shows West Wing and True Detective. It reflects on the modernist cuisine of Ferran Adrià and the fashion design of Issey Miyake. And, it dissects writing by Jenifer Egan, David Foster Wallace, David Mitchell, and Zadie Smith. Unpacking how the styles of these works detox, filter, binge, or ghost their worlds, Crisis Style is at once a taxonomy of contemporary cultural production and a theorization of action in a world always in need of repair. Ultimately, Dango presents a compelling argument for why we need aesthetic theory to understand what we're doing in our world today. (shrink)

Adam Smith and Thomas Reid follow Joseph Butler's lead in discussing the moral significance of resentment in great detail. David Hume does not. For Smith and Reid, resentment reveals shortcomings in Hume's attempt to ground justice solely in terms of self-interest and public utility. This can be seen most clearly in Reid's critique of Hume's response to the sensible knave. Reid argues that Hume's appeal to our integrity can have force only if Hume concedes that there are (...) elements of justice that are grounded in neither self-interest nor public utility. (shrink)

Preface Introduction Christopher J. Berry: Adam Smith: Outline of Life, Times, and Legacy Part One: Adam Smith: Heritage and Contemporaries 1: Nicholas Phillipson: Adam Smith: A Biographer's Reflections 2: Leonidas Montes: Newtonianism and Adam Smith 3: Dennis C. Rasmussen: Adam Smith and Rousseau: Enlightenment and counter-Enlightenment 4: Christopher J. Berry: Adam Smith and Early Modern Thought Part Two: Adam Smith on Language, Art and Culture 5: Catherine Labio: Adam Smith's Aesthetics 6: James (...) Chandler: Adam Smith as Critic 7: Michael C. Amrozowicz: Adam Smith: History and Poetics 8: C. Jan Swearingen: Adam Smith on Language and Rhetoric: The Ethics of Style, Character, and Propriety Part Three: Adam Smith and Moral Philosophy 9: Christel Fricke: Adam Smith: The Sympathetic Process and the Origin and Function of Conscience 10: Duncan Kelly: Adam Smith and the Limits of Sympathy 11: Ryan Patrick Hanley: Adam Smith and Virtue 12: Eugene Heath: Adam Smith and Self-Interest Part Four: Adam Smith and Economics 13: Tony Aspromourgos: Adam Smith on Labour and Capital 14: Nerio Naldi: Adam Smith on Value and Prices 15: Hugh Rockoff: Adam Smith on Money, Banking, and the Price Level 16: Maria Pia Paganelli: Commercial Relations: from Adam Smith to Field Experiments Part Five: Adam Smith on History and Politics 17: Spiros Tegos: Adam Smith: Theorist of Corruption 18: David M. Levy & Sandra J. Peart: Adam Smith and the State: Language and Reform 19: Fabrizio Simon: Adam Smith and the Law 20: Edwin van de Haar: Adam Smith on Empire and International Relations Part Six: Adam Smith on Social Relations 21: Richard Boyd: Adam Smith, Civility, and Civil Society 22: Gavin Kennedy: Adam Smith on Religion 23: Samuel Fleischacker: Adam Smith and Equality 24: Maureen Harkin: Adam Smith and Women Part Seven; Adam Smith: Legacy and Influence 25: Spencer J. Pack: Adam Smith and Marx 26: Craig Smith: Adam Smith and the New Right 27: Tom Campbell: Adam Smith: Methods, Morals and Markets 28: Amartya Sen: The Contemporary Relevance of Adam Smith. (shrink)

Through a glass darkly / Joshua Mitchell -- Skepticism, self, and toleration in Montaigne's political thought / Alan Levine -- French free-thinkers in the first decades of the Edict of Nantes / Maryanne Cline Horowitz -- Descartes and the question of toleration / Michael Gillepsie -- Toleration and the skepticism of religion in Spinoza's Tractatus Theologico-Politicus / Steven B. Smith -- Monopolizing faith / Alan Houston -- Skepticism and toleration in Hobbes' political thought / Shirley Letwin -- John (...) Locke and the foundations of toleration / Nathan Tarcov -- Pierre Bayle's atheist politics / Kenneth R. Weinstein -- Of believers and barbarians / Diana Schaub -- Tolerant skepticism of Voltaire and Diderot / Patrick Riley. (shrink)

Having its seeds in the 2nd International Lauener Symposium held in honour of Dagfinn Follesdal, the present collection contains a rich, kaleidoscopic ensemble of previously unpublished contributions by leading authors, representing diverse approaches to a variety of philosophical themes on which Follesdal has had a longstanding, formative impact. Follesdal himself contributes an orientating essay continuing to develop his pioneering theory of reference as well as in-depth commentaries on each of the other authors elaborated papers plus candid answers in the added (...) interview. The volume assembles a wealth of original articles containing in part direct discussions of Follesdal s work and covering a broad range of topics like subjectivity, intersubjectivity, objectivity, rationality, logics and mathematics, choice theory, values, modalities, intentionality, individuation, perception, communication, meaning, reference, the slingshot, one- and two-sorted semantics, evidence, neuropsychology, space and time, science and society, methodology, fallibilism, the relative a priori, justification, holism, the life-world, reflective equilibrium, empathy, and ethics. Moreover the book includes an incisive memoir of Follesdal the philosopher as well as a spanning interview with him, which are both critically directing toward Follesdal s subtly differentiated understanding of the dynamic philosophical horizon he shares in. With contributions from Dagfinn Follesdal, Charles Parsons, Patrick Suppes, Jon Elster, John Perry, Michael Friedman, Dag Prawitz, Wilhelm K. Essler, David Woodruff Smith, Olav Gjelsvik, Graciela De Pierris, Nils Roll-Hansen, Christian Beyer, Oystein Linnebo, Michael Frauchiger. Excerpt Open publication". (shrink)

In the mid-20th century, descriptive meta-ethics addressed a number of central questions, such as whether there is a necessary connection between moral judgment and motivation, whether moral reasons are absolute or relative, and whether moral judgments express attitudes or describe states of affairs. I maintain that much of this work in mid-20th century meta-ethics proceeded on an assumption that there is good reason to question. The assumption was that our ordinary discourse is uniform and determinate enough to vindicate one side (...) or the other of these meta-ethical debates. I suggest that ordinary moral discourse may be much less uniform and determinate than 20th century meta-ethics assumed. (shrink)

To Aaron Pacitti and Michael Cauvel–whose journal article, “Rent-Seeking Behavior and Economic Justice: A Classroom Exercise” broadly argues that “understanding the [complexities] of rent-seeking behavior helps fill the gap between economics and politics”–the varieties of rent are wide and, therefore, can only be described in their category-specific positions. I will discuss three of these categories in more detail below, but for now, I propose that a useful working grasp of economic rent involves “the amount paid to the owner of (...) a factor of production over the cost that is to be necessarily incurred on utilizing such elements in the production process.” In math terms, ‘economic rent’ equals the agreed-upon-amount paid by the consumer (when that amount far exceeds the market value of the product) minus the cost spent by the producer to make the product (when that cost is far below the typical amount to produce the product). Originally, the concept of economic rent concerned land ownership and the production of natural goods. Two major economists, Adam Smith and David Ricardo, offered insights into the general makeup and logic of what they called, the rent of land and simply rent, respectively. (shrink)

However, other leading philosophers of the era--such as David Hume, Adam Smith, and J.G. Herder--placed greater emphasis on feeling, seeing moral and political ...

Ingmar Persson and Julian Savulescu1 warn of our destruction by the cognitively enhanced beings we create. Now, in a fascinating paper, Nicholas Agar2 warns of an even more disturbing prospect: cognitively enhanced beings may be entitled to sacrifice us for their own ends. These post-humans would likely conclude that they had higher moral status than we mere human beings, and we would have good reason to defer to their vastly superior moral knowledge. We would lack even the consolation of moral (...) complaint.I will question both these claims: that we would have good reason to accept the conclusion of cognitively enhanced beings that they had superior moral status, and that they would be likely to reach such a conclusion . I will also question whether, if they were to have higher moral status, it would be wrong to create them, because it would be wrong to create beings with such costly needs.Agar argues that moral truths, including those about moral status, are like mathematical truths in eventually yielding to expert reasoning. This belief in moral enlightenment is extreme even for a moral realist. Michael Smith,3 whom Agar cites, merely adduces the gradual consensus that has emerged about issues that were once the subject of seemingly intractable disagreement: slavery, workers’ and women's rights and democracy. One may agree with Smith about slow, halting, moral progress, …. (shrink)

Many philosophical naturalists eschew analysis in favor of discovering metaphysical truths from the a posteriori, contending that analysis does not lead to philosophical insight. A countercurrent to this approach seeks to reconcile a certain account of conceptual analysis with philosophical naturalism; prominent and influential proponents of this methodology include the late David Lewis, Frank Jackson, Michael Smith, Philip Pettit, and David Armstrong. Naturalistic analysis is a tool for locating in the scientifically given world objects and properties (...) we quantify over in everyday discourse. This collection gathers work from a range of prominent philosophers who are working within this tradition, offering important new work as well as critical evaluations of the methodology. Its centerpiece is an important posthumous paper by David Lewis, "Ramseyan Humility," published here for the first time. The contributors first address issues of philosophy of mind, semantics, and the new methodology's a priori character, then turn to matters of metaphysics, and finally consider problems regarding normativity. Conceptual Analysis and Philosophical Naturalism is one of the first efforts to apply this approach to such a wide range of philosophical issues. _Contributors: _David Braddon-Mitchell, Mark Colyvan, Frank Jackson, Justine Kingsbury, Fred Kroon, David Lewis, Dustin Locke, Kelby Mason, Jonathan McKeown-Green, Peter Menzies, Robert Nola, Daniel Nolan, Philip Pettit, Huw Price, Denis Robinson, Steve Stich, Daniel Stoljar The hardcover edition does not include a dust jacket. (shrink)

This article sketches a theory of time-binding communication, which is to say communication that unifies widely separated times much as space-binding communication unifies widely separated places. Drawing from the work of Harold Innis, it first describes the function and character of time-binding communication as a means to social continuity. Then, following Alasdair MacIntyre and Michael Oakshott, it explains the nature and necessary circumstances of this sort of time-binding communication, or tradition. It discusses the character, consequences, and causes of decadence (...) - radical discontinuity - as these have been described by Richard Weaver, C. E. M. Joad, and Jacques Barzun. Finally, it turns to David Lowenthal's notion of the past as a 'foreign country' in an effort to explain the relations between modernity and both tradition and decadence, as well as the geography of tradition and decadence in the modern world. (shrink)

This essay compares Rawls's and Nozick's theories of justice. Nozick thinks patterned principles of justice are false, and offers a historical alternative. Along the way, Nozick accepts Rawls's claim that the natural distribution of talent is morally arbitrary, but denies that there is any short step from this premise to any conclusion that the natural distribution is unjust. Nozick also agrees with Rawls on the core idea of natural rights liberalism: namely, that we are separate persons. However, Rawls and Nozick (...) interpret that idea in different ways-momentously different ways. The tension between their interpretations is among the forces shaping political philosophy to this day. Footnotesa For comments, I thank Alyssa Bernstein, Geoffrey Brennan, Jason Brennan, Tom Christiano, Andrew I. Cohen, Andrew Jason Cohen, Tyler Cowen, Teresa Donovan, David Estlund, Jerry Gaus, Allen Habib, Alex Kaufman, Mark LeBar, Loren Lomasky (especially Loren, for insight and inspiration over a period of many years), Cara Nine, Ellen Frankel Paul, Guido Pincione, Thomas Pogge, Dan Russell, Michael Smith, Horacio Spector, and Matt Zwolinski. I thank the Earhart Foundation for financial support in the fall of 2002 and Australian National University's Research School of Social Sciences for its wonderful hospitality during a ten week stay in 2002. The support of the folks at Liberty Fund in Indianapolis during the final stages of this project goes beyond anything I will ever be able properly to thank them for. (shrink)

John Rawls shares the Enlightenment's commitment to finding moral and political principles which can be reflectively endorsed by all individuals autonomously. He usually presents reflective autonomy in Kantian, rationalist terms: autonomy is identified with the exercise of reason, and principles of justice must be constructed which are acceptable to all on the basis of reason alone. Yet David Hume, Adam Smith and many other Enlightenment thinkers rejected such rationalism, searching instead for principles which can be endorsed by all (...) on the basis of all the faculties of the human psyche, emotion and imagination included. The influence of these sentimentalists on Rawls is clearest in his descriptive moral psychology, but I argue that it is also present in Rawls's understanding of the sources of normativity. Although this debt is obscured by Rawls's explicit "Kantianism," his theory would be strengthened by a greater understanding of its debts to the sentimentalist Enlightenment. (shrink)